De Novo NT Cartilage Implantation

The De Novo NT Natural Tissue Graft procedure involves implantation of donor (allograft) viable juvenile cartilage into an area of cartilage damage. The advantage of the De Novo is that a biopsy is not required, and the turnaround time for implantation is much sooner after an initial diagnostic arthroscopy. In some cases, it may be appropriate to perform a De Novo procedure in a single stage. Because the juvenile cartilage is implanted using a fibrin glue, then there is no need for a periosteal flap or other matrix for implantation.

Who is a candidate for De Novo NT cartilage implantation?

DeNovo NT Graft is an FDA-listed tissue product used for knee, hip, ankle and shoulder cartilage restoration. It is indicated for lesion sizes greater than or equal to 2 cm2. However, ultimately the damaged cartilage area size, location, and specific patient factors will determine if you are a candidate for this procedure.

Is De Novo NT cartilage implantation safe?

Since 2007, there have been over 6,000 surgeries completed without any reports of graft rejection or disease transmission.

What are the outcomes of DeNovo NT cartilage implantation?

A recent study looked at 25 patients 2 years after De Novo NT implantation. In that study, all patients demonstrated a significant improvement in knee pain and function. In addition, MRI T2 mapping, and biopsy results of the implanted cartilage showed values approximating normal cartilage and histology results showed repaired tissue with hyaline cartilage and excellent integration.


Cole, B, Farr J, Tabet S, Gold G, Carlson C, Margerrison E. Clinical, Radiographic and Histological Outcomes following Cartilage Repair with Particulated Juvenile Articular Cartilage: A 2-Year Prospective Study. Am J Sports Med. 2014 Jun;42(6):1417-25. doi: 10.1177/0363546514528671. Epub 2014 Apr 9.

DeNovo NT Natural Tissue Graft, Zimmer Biomet Online.